The Effects of a Novel Taurine-L-Malic Acid Complex on Indices of Recovery after an Exercise Protocol Inducing Delayed-Onset Muscle Soreness Original Research

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Cassandra Evans
Jason Curtis
Flavia Pereira
Jose Rojas
Maria Berrocales
Kristiina Kinnunen
Kendall Andries
Leilani Batista
Robert Rocanelli
Juan Carlos Santana
Lia Jiannine
Jaime Tartar
Jose Antonio


pain, amino acids, supplements


Introduction: The purpose of this investigation was to determine the effects of a novel dietary supplement (Maltor™) on indices of muscle recovery after a delayed-onset muscle soreness (DOMS) protocol.

Methods:  In a double-blind, placebo-controlled, crossover trial, subjects consumed the treatment (i.e., 5 g. Maltor™ – a complex of taurine and L-malic acid in an approximately 2:1 ratio) and placebo (i.e.,1 g of sodium citrate and 4 g of maltodextrin) daily over 14 days. Subjects were instructed to consume the treatment or placebo for 14 days. After 14 days of consumption, subjects performed a DOMS protocol based on their 1-RM. Inflammatory markers, arm circumference, strength, subjective and objective measures of pain were assessed 24hr, 48hr and 72hrs after DOMS protocol.

Results: A statistically significant difference was found for the assessment of pain threshold via the pressure algometer (p=0.5). Subjects in the treatment group exhibited a higher pain threshold two days post-DOMS (i.e., delta score data). We found no significant differences between groups for arm circumference, 1-RM (p=0.66), pain assessed by VAS (0.94), or arm circumference (p=0.91) between the groups. Furthermore, there were no significant differences between groups for Interleukin-6 (p=0.85) and C-reactive protein (p=0.48), key markers of inflammation.

Conclusions: Based on this preliminary investigation, two weeks of consuming taurine-L-malic acid complex may diminish delayed-onset muscle soreness in exercise-trained males as assessed by an algometer (i.e., assessment of pain threshold).

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1. Hotfiel T, Freiwald J, Hoppe MW, et al. Advances in Delayed-Onset Muscle Soreness (DOMS): Part I: Pathogenesis and Diagnostics. Sportverletz Sportschaden. Dec 2018;32(4):243-250. Delayed Onset Muscle Soreness - Teil I: Pathogenese und Diagnostik. doi:10.1055/a-0753-1884
2. Faulkner JA, Brooks SV, Opiteck JA. Injury to skeletal muscle fibers during contractions: conditions of occurrence and prevention. Phys Ther. Dec 1993;73(12):911-21. doi:10.1093/ptj/73.12.911
3. MacIntyre DL, Reid WD, Lyster DM, McKenzie DC. Different effects of strenuous eccentric exercise on the accumulation of neutrophils in muscle in women and men. Eur J Appl Physiol. Jan 2000;81(1-2):47-53. doi:10.1007/PL00013796
4. Lewis PB, Ruby D, Bush-Joseph CA. Muscle soreness and delayed-onset muscle soreness. Clin Sports Med. Apr 2012;31(2):255-62. doi:10.1016/j.csm.2011.09.009
5. Kim J, Lee J. A review of nutritional intervention on delayed onset muscle soreness. Part I. J Exerc Rehabil. Dec 2014;10(6):349-56. doi:10.12965/jer.140179
6. Cheung K, Hume P, Maxwell L. Delayed onset muscle soreness : treatment strategies and performance factors. Sports Med. 2003;33(2):145-64. doi:10.2165/00007256-200333020-00005
7. Schaffer SW, Jong CJ, Ramila KC, Azuma J. Physiological roles of taurine in heart and muscle. J Biomed Sci. Aug 24 2010;17 Suppl 1(Suppl 1):S2. doi:10.1186/1423-0127-17-s1-s2
8. McLeay Y, Stannard S, Barnes M. The Effect of Taurine on the Recovery from Eccentric Exercise-Induced Muscle Damage in Males. Antioxidants (Basel). Oct 17 2017;6(4)doi:10.3390/antiox6040079
9. Kontny E, Szczepańska K, Kowalczewski J, et al. The mechanism of taurine chloramine inhibition of cytokine (interleukin-6, interleukin-8) production by rheumatoid arthritis fibroblast-like synoviocytes. Arthritis Rheum. Oct 2000;43(10):2169-77. doi:10.1002/1529-0131(200010)43:10<2169::Aid-anr4>3.0.Co;2-#
10. Schaffer S, Kim HW. Effects and Mechanisms of Taurine as a Therapeutic Agent. Biomol Ther (Seoul). May 1 2018;26(3):225-241. doi:10.4062/biomolther.2017.251
11. Haddad A, Mohiuddin SS. Biochemistry, Citric Acid Cycle. StatPearls. 2024.
12. Wei Z, Xu Y, Xu Q, Cao W, Huang H, Liu H. Microbial Biosynthesis of L-Malic Acid and Related Metabolic Engineering Strategies: Advances and Prospects. Front Bioeng Biotechnol. 2021;9:765685. doi:10.3389/fbioe.2021.765685
13. Ra SG, Miyazaki T, Ishikura K, et al. Additional effects of taurine on the benefits of BCAA intake for the delayed-onset muscle soreness and muscle damage induced by high-intensity eccentric exercise. Adv Exp Med Biol. 2013;776:179-87. doi:10.1007/978-1-4614-6093-0_18
14. Cerqueira É, Marinho DA, Neiva HP, Lourenço O. Inflammatory Effects of High and Moderate Intensity Exercise-A Systematic Review. Front Physiol. 2019;10:1550. doi:10.3389/fphys.2019.01550
15. Docherty S, Harley R, McAuley JJ, et al. The effect of exercise on cytokines: implications for musculoskeletal health: a narrative review. BMC Sports Science, Medicine and Rehabilitation. 2022/01/06 2022;14(1):5. doi:10.1186/s13102-022-00397-2
16. da Silva LA, Tromm CB, Bom KF, et al. Effects of taurine supplementation following eccentric exercise in young adults. Appl Physiol Nutr Metab. Jan 2014;39(1):101-4. doi:10.1139/apnm-2012-0229
17. Wang Y, Xu T, Zhao H, Gu C, Li Z. Effect of taurine in muscle damage markers and inflammatory cytokines in running exercise. Original Research. Frontiers in Physiology. 2022-September-13 2022;13doi:10.3389/fphys.2022.1008060
18. Krebs HA, Salvin E, Johnson WA. The formation of citric and alpha-ketoglutaric acids in the mammalian body. Biochem J. Jan 1938;32(1):113-7. doi:10.1042/bj0320113
19. Gough LA, Sparks SA, McNaughton LR, et al. A critical review of citrulline malate supplementation and exercise performance. Eur J Appl Physiol. Dec 2021;121(12):3283-3295. doi:10.1007/s00421-021-04774-6
20. Abraham GE, Flechas JD. Management of Fibromyalgia: Rationale for the Use of Magnesium and Malic Acid. Journal of Nutritional Medicine. 1992/01/01 1992;3(1):49-59. doi:10.3109/13590849208997961
21. Borst P. The malate-aspartate shuttle (Borst cycle): How it started and developed into a major metabolic pathway. IUBMB Life. Nov 2020;72(11):2241-2259. doi:10.1002/iub.2367