The Influence of Aerobic Exercise Training on Adipokine Concentrations in Obese Men Review

Main Article Content

Leroy Bolden
Tomas Chapman-Lopez
Dillon Harris
Olivia Russell
Katherine Lee
Mary Pickler
LesLee Funderburk
Andrew Gallucci

Keywords

Adipokines, Aerobic Exercise, Obese Males, Omentin-1, Adiponectin , Leptin

Abstract

The rise of obesity and physical inactivity has elicited changes in body composition that negatively influence adipokine concentrations. While literature is limited to the vast majority of adipokines, several have been shown to play key roles in metabolism and inflammatory pathways. As a result, various comorbidities (e.g., hypertension, hypercholesterolemia, osteoporosis, diabetes mellitus, sarcopenia) have become more prevalent in individuals who possess an overabundance of adipose tissue. This may be attributed to the increase of pro-inflammatory adipokines as adipose tissue increases. However, some recent interventions have gained popularity [e.g., resistance training, aerobic exercise training (AET), nutrition] and have been shown to be effective in improving body composition in obese populations. More recently, studies have shown resistance training could be effective at improving pro- and anti-inflammatory adipokine concentrations and regulation (e.g., leptin, adiponectin, omentin-1, visfatin) by altering lean-muscle mass/fat-mass ratio. However, there have only been a few studies assessing how AET could also be effective in managing adipokine concentrations. Therefore, the focus of this review is to build a comprehensive understanding of the benefits of AET’s influence on pro- and anti-inflammatory adipokine concentrations in obese males.

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References


1. Hales CM. Prevalence of Obesity and Severe Obesity Among Adults: United States, 2017–2018. 2020;(360):8.
2. Kyrou I, Randeva HS, Tsigos C, Kaltsas G, Weickert MO. Clinical Problems Caused by Obesity. In: Feingold KR, Anawalt B, Boyce A, et al., eds. Endotext. MDText.com, Inc.; 2000. Accessed October 30, 2022. http://www.ncbi.nlm.nih.gov/books/NBK278973/
3. CDC. Why It Matters. Centers for Disease Control and Prevention. July 14, 2022. Accessed October 30, 2022. https://www.cdc.gov/obesity/about-obesity/why-it-matters.html
4. Golbidi S, Laher I. Exercise induced adipokine changes and the metabolic syndrome. J Diabetes Res. 2014;2014:726861. doi:10.1155/2014/726861
5. Freitas Lima LC, Braga V de A, do Socorro de França Silva M, et al. Adipokines, diabetes and atherosclerosis: an inflammatory association. Front Physiol. 2015;6. Accessed October 30, 2022. https://www.frontiersin.org/articles/10.3389/fphys.2015.00304
6. Pereira SS, Alvarez-Leite JI. Adipokines: biological functions and metabolically healthy obese profile. J Recept Ligand Channel Res. 2014;7:15-25. doi:10.2147/JRLCR.S36060
7. Mancuso P. The role of adipokines in chronic inflammation. ImmunoTargets Ther. 2016;5:47-56. doi:10.2147/ITT.S73223
8. Schwingshackl L, Hoffmann G. Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials. Nutr Metab Cardiovasc Dis NMCD. 2014;24(9):929-939. doi:10.1016/j.numecd.2014.03.003
9. Chapman-Lopez T, Wilburn D, Fletcher E, et al. The influence of resistance training on adipokines in post-menopausal women: A brief review. Sports Med Health Sci. Published online September 20, 2022. doi:10.1016/j.smhs.2022.09.001
10. Mika A, Macaluso F, Barone R, Di Felice V, Sledzinski T. Effect of Exercise on Fatty Acid Metabolism and Adipokine Secretion in Adipose Tissue. Front Physiol. 2019;10. Accessed October 30, 2022. https://www.frontiersin.org/articles/10.3389/fphys.2019.00026
11. Auerbach P, Nordby P, Bendtsen LQ, et al. Differential effects of endurance training and weight loss on plasma adiponectin multimers and adipose tissue macrophages in younger, moderately overweight men. Am J Physiol Regul Integr Comp Physiol. 2013;305(5):R490-498. doi:10.1152/ajpregu.00575.2012
12. Kolnes KJ, Petersen MH, Lien-Iversen T, Højlund K, Jensen J. Effect of Exercise Training on Fat Loss—Energetic Perspectives and the Role of Improved Adipose Tissue Function and Body Fat Distribution. Front Physiol. 2021;12. Accessed October 30, 2022. https://www.frontiersin.org/articles/10.3389/fphys.2021.737709
13. Nguyen TMD. Adiponectin: Role in Physiology and Pathophysiology. Int J Prev Med. 2020;11:136. doi:10.4103/ijpvm.IJPVM_193_20
14. Sena CM. Omentin: A Key Player in Glucose Homeostasis, Atheroprotection, and Anti-Inflammatory Potential for Cardiovascular Health in Obesity and Diabetes. Biomedicines. 2024;12(2):284. doi:10.3390/biomedicines12020284
15. Obradovic M, Sudar-Milovanovic E, Soskic S, et al. Leptin and Obesity: Role and Clinical Implication. Front Endocrinol. 2021;12:585887. doi:10.3389/fendo.2021.585887
16. Parastesh M, Alibakhshi E, Saremi A, Shavandi N. The effect of aerobic exercise training on leptin and pulmonary function tests during weight loss in men with visceral obesity. J Shahrekord Univ Med Sci. 2020;22(2):96-101.
17. Besse-Patin A, Montastier E, Vinel C, et al. Effect of endurance training on skeletal muscle myokine expression in obese men: identification of apelin as a novel myokine. Int J Obes. 2014;38(5):707-713.
18. Atashak S, Stannard SR, Daraei A, et al. High-intensity Interval Training Improves Lipocalin-2 and Omentin-1 Levels in Men with Obesity. Int J Sports Med. 2022;43(4):328-335. doi:10.1055/a-1560-5401
19. Krause M, Rodrigues-Krause J, O’Hagan C, et al. The effects of aerobic exercise training at two different intensities in obesity and type 2 diabetes: implications for oxidative stress, low-grade inflammation and nitric oxide production. Eur J Appl Physiol. 2014;114(2):251-260. doi:10.1007/s00421-013-2769-6
20. Ozias MK, Li S, Hull HR, Brooks WM, Carlson SE. Relationship of circulating adipokines to body composition in pregnant women. Adipocyte. 2015;4(1):44-49. doi:10.4161/adip.29805
21. Shah A, Hernandez A, Mathur D, Budoff MJ, Kanaya AM. Adipokines and body fat composition in South Asians: results of the Metabolic Syndrome and Atherosclerosis in South Asians Living in America (MASALA) study. Int J Obes 2005. 2012;36(6):810-816. doi:10.1038/ijo.2011.167
22. Marshall JA, Grunwald GK, Donahoo WT, Scarbro S, Shetterly SM. Percent body fat and lean mass explain the gender difference in leptin: analysis and interpretation of leptin in Hispanic and non-Hispanic white adults. Obes Res. 2000;8(8):543-552. doi:10.1038/oby.2000.70
23. Ouchi N, Parker JL, Lugus JJ, Walsh K. Adipokines in inflammation and metabolic disease. Nat Rev Immunol. 2011;11(2):85-97. doi:10.1038/nri2921
24. Ondrak KS, Hackney AC. Body composition differences in normal weight, obese-overweight and anorexic adolescents: role of adipocytokines. Med Sport Sci. 2010;55:32-42. doi:10.1159/000321970
25. Chapman-Lopez TJ, Funderburk LK, Heileson JL, et al. Effects of L-Leucine Supplementation and Resistance Training on Adipokine Markers in Untrained Perimenopausal and Postmenopausal Women. J Strength Cond Res. 2024;38(3):526-532. doi:10.1519/JSC.0000000000004661
26. CDC. Defining Adult Overweight and Obesity. Centers for Disease Control and Prevention. June 3, 2022. Accessed October 30, 2022. https://www.cdc.gov/obesity/basics/adult-defining.html
27. Lehr S, Hartwig S, Sell H. Adipokines: a treasure trove for the discovery of biomarkers for metabolic disorders. Proteomics Clin Appl. 2012;6(1-2):91-101. doi:10.1002/prca.201100052
28. Zhao A, Xiao H, Zhu Y, et al. Omentin-1: a newly discovered warrior against metabolic related diseases. Expert Opin Ther Targets. 2022;26(3):275-289. doi:10.1080/14728222.2022.2037556
29. Ouerghi N, Fradj MKB, Duclos M, et al. Effects of High-Intensity Interval Training on Selected Adipokines and Cardiometabolic Risk Markers in Normal-Weight and Overweight/Obese Young Males—A Pre-Post Test Trial. Biology. 2022;11(6):853. doi:10.3390/biology11060853
30. Mousavi SM, Heidarianpour A, Tavassoli H. Aerobic Exercise Training Effects on Omentin-1, Insulin Resistance, and Lipid Profile Among Male Smokers. Res Q Exerc Sport. Published online May 17, 2022:1-6. doi:10.1080/02701367.2022.2070116

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