Concerns over the Utility of Phase Angle and its Association with Muscle Function Commentary
Main Article Content
Keywords
bioelectrical impedance analysis, strength athletes, body composition, recovery
Abstract
Introduction: Phase angle (PhA) derived from bioelectrical impedance analysis (BIA) has been used as an indicator of cellular hydration, muscle function, and nutritional status. Positive relationships between PhA and various measures of muscle function have been reported but it remains unclear whether PhA retains its predictive utility of muscle function, or whether it performs better than fat-free mass (FFM) in the context of muscle function.
Methods: This perspective highlights secondary analyses of data collected during a randomized, double-blind, placebo-controlled trial that examined indices of recovery with different whey protein supplements after muscle-damaging exercise among resistance-trained adults.
Results: Bivariate correlations between phase angle and quadriceps twitch force were positively correlated at baseline, 24-h, and 72-h post-exercise. In linear regression, FFM was shown to account for nearly 44% (partial r = 0.662) of the variance in quadriceps twitch force independent of phase angle at 24-h. A similar pattern emerged at 48-h and 72-h post-exercise
Conclusions: Within this framework, these data demonstrate that: 1) PhA exhibits a weaker correlation to quadriceps twitch force compared to FFM and 2) in the context of muscle function, PhA does not provide additional information beyond that of FFM alone. Investigators should consider adjusting for FFM when evaluating the relationship between PhA and muscle function outcomes.
References
2. Lukaski HC, Talluri A. Phase angle as an index of physiological status: validating bioelectrical assessments of hydration and cell mass in health and disease. Rev Endocr Metab Disord. 2023;24(3):371-379. doi:10.1007/s11154-022-09764-3
3. Akamatsu Y, Kusakabe T, Arai H, et al. Phase angle from bioelectrical impedance analysis is a useful indicator of muscle quality. J Cachexia Sarcopenia Muscle. 2022;13(1):180-189. doi:10.1002/jcsm.12860
4. Sardinha LB, Rosa GB. Phase angle, muscle tissue, and resistance training. Rev Endocr Metab Disord. 2023;24(3):393-414. doi:10.1007/s11154-023-09791-8
5. Basile C, Della-Morte D, Cacciatore F, et al. Phase angle as bioelectrical marker to identify elderly patients at risk of sarcopenia. Exp Gerontol. 2014;58:43-46. doi:10.1016/j.exger.2014.07.009
6. Cunha PM, Tomeleri CM, Nascimento MA do, et al. Improvement of cellular health indicators and muscle quality in older women with different resistance training volumes. J Sports Sci. 2018;36(24):2843-2848. doi:10.1080/02640414.2018.1479103
7. Bourgeois B, Fan B, Johannsen N, et al. Improved strength prediction combining clinically available measures of skeletal muscle mass and quality. J Cachexia Sarcopenia Muscle. 2019;10(1):84-94. doi:10.1002/jcsm.12353
8. Custódio Martins P, de Lima TR, Silva AM, Santos Silva DA. Association of phase angle with muscle strength and aerobic fitness in different populations: A systematic review. Nutr Burbank Los Angel Cty Calif. 2022;93:111489. doi:10.1016/j.nut.2021.111489
9. Fukuoka AH, de Oliveira NM, Matias CN, et al. Association between Phase Angle from Bioelectric Impedance and Muscular Strength and Power in Physically Active Adults. Biology. 2022;11(9):1255. doi:10.3390/biology11091255
10. Bongiovanni T, Rossi A, Trecroci A, et al. Regional Bioelectrical Phase Angle Is More Informative than Whole-Body Phase Angle for Monitoring Neuromuscular Performance: A Pilot Study in Elite Young Soccer Players. Sports Basel Switz. 2022;10(5):66. doi:10.3390/sports10050066
11. Varanoske AN, Harris MN, Hebert C, et al. Bioelectrical impedance phase angle is associated with physical performance before but not after simulated multi-stressor military operations. Physiol Rep. 2023;11(6):e15649. doi:10.14814/phy2.15649
12. Barenie MJ, Escalera A, Carter SJ, et al. Grass-Fed and Non-Grass-Fed Whey Protein Consumption Do Not Attenuate Exercise-Induced Muscle Damage and Soreness in Resistance-Trained Individuals: A Randomized, Placebo-Controlled Trial. J Diet Suppl. Published online November 20, 2023:1-30. doi:10.1080/19390211.2023.2282470
13. Hirata K, Yamada Y, Iida N, et al. Relation of leg phase angle from bioelectrical impedance analysis with voluntary and evoked contractile properties of the plantar flexors. Front Physiol. 2023;14:1292778. doi:10.3389/fphys.2023.1292778
14. Hirata K, Ito M, Nomura Y, Yoshida T, Yamada Y, Akagi R. Can phase angle from bioelectrical impedance analysis associate with neuromuscular properties of the knee extensors? Front Physiol. 2022;13:965827. doi:10.3389/fphys.2022.965827
15. Matias CN, Campa F, Nunes CL, et al. Phase Angle Is a Marker of Muscle Quantity and Strength in Overweight/Obese Former Athletes. Int J Environ Res Public Health. 2021;18(12):6649. doi:10.3390/ijerph18126649
16. Di Vincenzo O, Marra M, Sammarco R, Speranza E, Cioffi I, Scalfi L. Body composition, segmental bioimpedance phase angle and muscular strength in professional volleyball players compared to a control group. J Sports Med Phys Fitness. 2020;60(6):870-874.
17. Langer RD, Guimarães RF, Guerra-Júnior G, Gonçalves EM. Can Phase Angle Be Associated With Muscle Strength in Healthy Male Army Cadets? Mil Med. 2023;188(7-8):e1935-e1940. doi:10.1093/milmed/usac007
18. Hetherington-Rauth M, Leu CG, Júdice PB, Correia IR, Magalhães JP, Sardinha LB. Whole body and regional phase angle as indicators of muscular performance in athletes. Eur J Sport Sci. Published online 2020:1-22.