Resistance Training vs. Hormone Replacement Therapy: Can Training Offset Perimenopausal Hormonal Shifts? Commentary
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Keywords
Menstrual cycle, female physiology, Resistance training, estrogen
Abstract
Perimenopause is a hormonally dynamic transition characterized by erratic declines in 17-β-estradiol, leading to a wide array of physiological and psychosocial symptoms that can significantly impact quality of life. While hormone replacement therapy (HRT) is effective for many, it is not a viable option for all due to medical contraindications and potential risks. This commentary explores resistance training (RT) as a non-pharmacological alternative for managing perimenopausal symptoms. RT has demonstrated benefits in mitigating metabolic dysfunction, improving mood and cognitive health, and potentially alleviating vasomotor symptoms through mechanisms that partially mimic estrogen’s effects. Despite these promising outcomes, RT remains underrepresented in perimenopausal research compared to other exercise modalities. Future studies are needed to assess the effectiveness of RT alone and in combination with HRT to better inform evidence-based strategies for improving female health during this critical life stage.
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Copyright, 2025 by the authors. This work is licensed under the Creative Commons Attribution 4.0 International License.
Dr. Antonella V. Schwarz, Barry University
Assitant Professor
Department of Kinesiology and Sport Sciences
Anna L. Oelmann, University of South Florida
Research Coordinator and Graduate Assistant
Dr. Alyssa L. Parten , University of Alabama
Clinical Assitant Professor
Department of Kinesiology